Mueller S, Kline CN, Buerki RA, et al. - Researchers sought to evaluate the effect of stroke and stroke recurrence on all-cause late mortality (> 5 years from cancer diagnosis), as well as on multiple aspects of psychological and socioeconomic outcomes within the Childhood Cancer Survivor Study (CCSS), a retrospective cohort study with longitudinal follow-up concerning survivors of pediatric cancer who were diagnosed between 1970 and 1986. Among 14,358 candidates, median age was 39.7 years, 224 had a stroke after their cancer diagnosis (single stroke in 161 individuals and recurrent stroke in 63 individuals). All-cause late mortality rates were 0.70 prior to stroke, 1.03 after the first stroke, and 2.42 after the recurrent stroke based on 2,636 deaths. Among 7,304 survivors, those with stroke were more inclined to live with a caregiver vs stroke-free survivors. Stroke and stroke recurrence in pediatric cancer survivors are associated with increased mortality and negative impact of health-related quality of life interventions.