Song H, Fall K, Fang F, et al. – Researchers determined if severe psychiatric reactions to trauma and other adversities are correlated with subsequent risk of life threatening infections via performing a sibling controlled cohort study. Participants included 144,919 people with stress-related disorders (identified from 1987 to 2013) compared with 184,612 full siblings of individuals with a diagnosed stress-related disorder and 1,449,190 matched people without such a diagnosis from the general population. According to findings, the average age when a stress-related disorder was diagnosed was 37 years. Findings suggested an association of younger age at diagnosis of a stress-related disorder and the presence of psychiatric comorbidity, particularly substance use disorders, with higher HRs. Furthermore, use of selective serotonin reuptake inhibitors in the first year after diagnosis of a stress-related disorder was related to attenuated HRs. After controlling for familial background and physical or psychiatric comorbidities, stress-related disorders were linked to a subsequent risk of life-threatening infections including sepsis, endocarditis, CNS infections, and fatal infections of any other origin.