Stratification of pregnancy care based on risk of pre‐eclampsia derived from uterine artery Doppler at 19–24 weeks’ gestation
Ultrasound in Obstetrics & Gynecology Mar 09, 2021
Litwinska M, Litwinska E, Lisnere K, et al. - This prospective, non‐intervention study of women attending for an ultrasound scan at 19‐24 weeks as part of routine pregnancy care, was conducted with two goals. First, researchers here investigated the utility of uterine artery pulsatility index (UtA‐PI) at 19‐24 weeks’ gestation in the prediction of subsequent development of preeclampsia (PE), as well as compared the performance of screening between the use of first, fixed cut‐offs of UtA‐PI, second, percentile cut‐offs in UtA‐PI adjusted for gestational age, third, competing risks model combining maternal demographic characteristics and medical history with UtA‐PI, and fourth, competing risks model combining maternal factors with UtA‐PI and mean arterial pressure (MAP). Second, they sought to perform stratification of pregnancy care based on determined risk of preeclampsia (PE) at 19‐24 weeks’ gestation from UtA‐PI and combinations of maternal factors with UtA‐PI and MAP. The study population comprised 96,678 singleton pregnancies; among these, there were 2,866 (3.0%) that subsequently developed PE, including 467 (0.5%) that delivered at < 36 weeks’ gestation. Based on findings, they advice that screening for PE should be done at 20 and 36 weeks’ gestation among all pregnant women. The subgroups requiring additional monitoring and reassessment at 28 and 32 weeks can be identified using the findings at 20 weeks. Superior performance was recorded for screening by a combination of maternal factors and multiple of the median (MoM) values of UtA‐PI and MAP at 19‐24 weeks for delivery with PE at < 28, < 32 and < 36 weeks’ gestation relative to screening by a combination of maternal factors and UtA‐PI MoM or fixed cut‐offs of UtA‐PI or percentile cut‐offs in UtA‐PI.
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