Setién-Suero E, Neergaardd K, de la Foz VOG, et al. - In this investigation involving 209 first episode of psychosis patients, researchers studied the long-term (up to 10 years) patterns associated with cannabis use and the impact that consumption might have on clinical, functioning, and neurocognition at long-term. According to cannabis use, study participants were divided into three groups: persistent users, ex-users, and never-users. At 10-year follow-up, clinical variations were found among persistent cannabis users and the other two groups (ex-users and non-users), indicating more severe symptoms and poorer functionality between persistent users. Ex-users who stopped cannabis use before reassessment displayed a comparable pattern to those who had never consumed. The use of cannabis can adversely affect psychotic disorder's evolution. With the cessation of use, the negative effects caused by cannabis use can be reversed. In the intervention, an attempt must be made to early withdrawal from the use of cannabis, as this could play an important role in the disease prognosis.