Stokkeland K, et al. - In 2914 patients with primary sclerosing cholangitis (PSC), researchers carried out a nationwide study in Sweden to determine the effects of drug exposure, including statins. From 2005 to 2014, they studied a population-based cohort of patients in Sweden with PSC and concomitant ulcerative colitis or Crohn's disease, followed by 2016. Risk or death, liver transplantation, bleeding of esophageal varices, and cancer in relation to drug exposure were calculated. They observed that the mean age of patients at the time of diagnosis with PSC was 41.4 years. Findings suggested an association of statin use with a reduced risk of all-cause mortality and death or liver transplantation. In addition, azathioprine use was linked to decreased mortality and risk of death or liver transplantation. Data reported that mortality was not affected by exposure to ursodeoxycholic acid.