Tonelli M, et al. - Researchers examined the link between statin use and hospitalization with acute kidney injury (AKI) in this population-based cohort study in Alberta. Participants included 128,140 new statin users aged ≥ 66 years who were not receiving renal replacement therapy at baseline. Among these, high- and medium-intensity regimens were prescribed at the index date to 47% and 46%, respectively. Significant increases in the adjusted risks of hospitalization with AKI were observed in relation to the use of high- and medium-intensity statin regimens vs non-use. Compared with men, women had a higher risk of AKI. Also, users of angiotensin converting enzyme inhibitors/angiotensin receptor blockers vs non-users, and diuretic users, were at higher risk of developing AKI. Findings revealed that the intensity of statin use was related to the risk of hospitalization with AKI; this was a graded, independent link, although the absolute magnitude of the excess risk was small.