Jo S, Won EJ, Kim MJ, et al. - The present study was conducted to assess if a signal transducer and activator of transcription 3 phosphorylation inhibitor (stat3-p Inh) could treat both chronic inflammation and bone formation in Ankylosing spondylitis (AS). Researchers evaluated primary AS osteoprogenitor cells and spinal entheseal cells for osteogenic differentiation. They collected synovial fluid mononuclear cells (SFMCs) and lamina propria mononuclear cells from AS patients. It was shown that in AS, Stat-3p inhibition is a promising treatment for both inflammation and new bone formation.