Nazir S, et al. - Researchers analyzed 95 articles with 100 patients in this systematic review to assess the clinical presentation and management of ST-elevation myocardial infarction (STEMI) as a complication of infective endocarditis (IE). They included relevant articles on STEMI related to IE and analyzed demographic variables, key clinical features upon presentation, treatment strategies, and clinical outcomes. The included patient population was 53 ± 17 years (mean age) at presentation and most of the participants were male (n = 63, 63%). In patients with STEMI with recent IE, new precordial murmur, fever, increased leukocyte count or other embolic events, septic emboli could all be considered as a cause for STEMI. Although no clarity has been gained regarding the best practices for management, significant bleeding and embolic risks were reported with thrombolytics.