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Spontaneous preterm birth and cervical length in a pregnant Asian population

PLoS Neglected Tropical Diseases Apr 16, 2020

Thain S, et al. - Researchers investigated the rate of spontaneous preterm birth in a pregnant Asian population. Further, they examined how preterm birth is associated with cervical length. In this prospective observational study conducted between September 2010 and November 2013 at KK Women’s and Children’s Hospital, Singapore, 1,013 women with single viable pregnancies were assessed for cervical length measures using ultrasound at each of the 4 antenatal visits (Visit 1: < 14 weeks, Visit 2: 18–22 weeks, Visit 3: 28–32 weeks and Visit 4: > 34 weeks) using the Fetal Medicine Foundation protocol. Analysis suggest that preterm birth group exhibits a significantly shorter cervical length in the 2nd and 3rd trimester. They identified cervical length as a moderate predictor of preterm birth. It had good negative predictive value with a relatively good specificity. Among pregnant Asian women, a group of women who are at risk for preterm birth could be recognized via performing ultrasound cervical length screening between 18 and 22 weeks of gestation with a cutoff of ≥ 2.48 cm.

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