Hebert JJ, et al. - Via a study on 1,022 children, researchers analyzed the prospective correlations of spinal pain exposures with risk factors for cardiovascular disease and investigated ifhealth-related physical activity plays a mediating role. No associations between spinal pain and cardiovascular risk in boys were noted; however, girls with spinal pain had greater clustered cardiovascular risk vs those without spinal pain. Further, this relationship was not mediated by moderate-to-vigorous-intensity physical activity. Independent of health-related physical activity, a possibly important connection between spinal pain and cardiovascular risk in girls was observed.