Lowe CC, Stogner JM, Miller BL., et al. - By investigating the factors linked with synthetic cannabinoid (SC) use, researchers aimed at presenting an updated profile of school-aged synthetic cannabinoid users in the US. They used bivariate analyses and logistic regression models to analyze data from the 2015 and 2017 Youth Risk Behavior Survey (YBRS), a nationally-representative survey of high school students in the US. SC use was reported by 8.0% of respondents, though fewer than half of these users (3.6%) reported using SC three or more times. Higher likelihood of both lifetime and persistent use was observed for older youths, males, and lesbian, gay and bisexual youths. Relative to White and African American youths, Asian youths are less likely to report ever using SC, while lifetime and persistent use are identified to be more frequent among Hispanic youths. A positive correlation of poor academic performance and using other substances was observed with lifetime and persistent use. At-risk groups should be targeted by policy makers and practitioners with evidence-based substance use prevention programs and practices, and awareness concerning the legal, medical, and social risks associated with SC use should continuously be promoted.