Rondon AJ, Paziuk T, Gutman MJ, et al. - Researchers aimed at determining mortality and functional outcomes linked with definitive spacer placement for periprosthetic joint infection (PJI) following shoulder arthroplasty. Following IRB approval (#20E.1315), they conducted a retrospective chart review identifying 17 patients managed with definitive antibiotic spacer placement (18 spacers) and followed for a minimum of 2 years after surgery. Among patients, treatment with retained antibiotic spacer was done at a mean age of 62.4 (range 50-73). Occurrence of spacer placement was observed at a mean of 6.1 years (range 0.48 - 14.9 years) following index arthroplasty. Cutibacterium acnes (6), Methicillin sensitive Staphylococcus aureus (MSSA) (6), Methicillin resistant Staphylococcus aureus (MRSA) (2), coagulase negative Staphylococcus (2), Serratia marcescens (1), gram-positive cocci (1), Enterobacter faecalis (1), Enterobacter cloacae (1), Diphtheroids (1), and culture negative (1) were the most common organisms. Overall findings suggest definitive antibiotic spacer placement as an acceptable strategy to treat infection in medically frail patients who have a high mortality risk. Spacer exchange may be necessary due to persistent infection, and poor functional results are evident.