Arrigo M, et al. - Researchers intended to dissect overhydration (OH) into its major functional components by combined use of bioimpedance measurements, cardiovascular biomarkers, and echocardiography, and prospectively tested the link between cardiac and non-cardiac components of OH with mortality in haemodialysis (HD) patients. In a cohort of 30 HD patients, soluble CD146 (sCD146) was validated as a non-cardiac biomarker of systemic congestion. A prospective 1-year follow-up in an independent cohort of 144 HD patients was also performed. OH was dissected into functional components of prognostic value using the combination of BNP and sCD146. In HD patients, OH was found to be related to higher mortality only if resulting from cardiac dysfunction.