Nomah DK, Reyes-Urueña J, Díaz Y, et al. - An elevated risk of severe outcomes from COVID-19 could exist in people living with HIV with detectable HIV viremia, chronic comorbidities, and in some subpopulations. Prioritizing these groups in clinical management and SARS-CoV-2 vaccination programs is recommended.

• A retrospective cohort study of 749 people with HIV who were diagnosed with SARS-CoV-2 in Catalonia (Spain).

• Migrants, men who have sex with men, and those with four or more chronic comorbidities more commonly received SARS-CoV-2 diagnosis, with adjusted hazard ratios 1·55, 1·42, and 1·46, respectively.

• Factors linked with elevated risk of severe outcomes included: age at least 75 years (5·2), non-Spanish origin (2·1), and neuropsychiatric (1·69), autoimmune disease (1·92), respiratory disease (1·84) and metabolic disease (2·59) chronic comorbidities.

• Risk of severe outcomes, by CD4 cell count, differed in patients with detectable HIV RNA but there were no differences in those with undetectable HIV RNA.