Rudolph AE, Upton E, Young AM, et al. - This study was intended to assess social network prognosticators of recent (self‐report injection followed by non‐injection) and sustained (self‐report non‐injection at two consecutive visits among those who previously injected) injection cessation in Appalachian Kentucky. Researchers obtained data through bi‐annual longitudinal assessments for Social Networks among Appalachian People (SNAP; 2008–17). They regressed non‐injection status on the number of social network members who (a) did not inject and (b) recently stopped injecting and tested for interactions between each social network exposure and prior non‐injection status applying logistic regression with generalized estimating equations that clustered on individuals. A total of 326 patients were included in the study. An increased odds of recent and sustained injection cessation were reported among people with a history of injection drug use in Appalachian Kentucky for each additional network member who did not inject drugs.