Wang E, et al. - The literature on associations between social determinants of health and pregnancy-related mortality and morbidity in the United States was synthesized. In addition, opportunities for intervention and future research have been highlighted. Performing a systematic search using Ovid MEDLINE, CINAHL, Popline, Scopus, and ClinicalTrials.gov (1990–2018) using MeSH terms related to maternal mortality, morbidity, and social determinants of health, and limited to the United States, researchers selected studies investigating correlations between social determinants and adverse maternal outcomes including pregnancy-related death, severe maternal morbidity, and emergency hospitalizations or readmissions. Three authors screened abstracts and two screened full articles for inclusion using Covidence. Analysis was performed of a total of 83 studies meeting the inclusion criteria. Evidence was gained from the empirical studies supporting the role of race and ethnicity, insurance, and education in pregnancy-related mortality and severe maternal morbidity risk. However, greater depth studies are required for many other important social determinants, including mechanisms of effect.