Kim JH, et al. - Whether both short and long sleep duration are associated with higher mortality in coronary artery disease (CAD), was determined in 2,846 patients enrolled in the Emory Cardiovascular Biobank (mean age 64 years, 38% female, 23% Black, and 82% with obstructive CAD, defined by positive coronary angiography). These subjects were examined with respect to sleep durations, all-cause and cardiovascular mortality, using multivariate Cox proportional hazard models. For 39%, 26% and 35% of the cohort, sleep durations of <6.5 hours (short), ≥6.5 to <7.5 hours (normal), and ≥ 7.5 hours (long), respectively, were reported, with mortality rates being 15%, 11%, and 17%, respectively, as observed during follow-up (median 2.8 years). This is the first investigation to extend the observations of sleep duration and mortality from population-based studies to patients with documented cardiac disease. The independent association of both short and long sleep duration with higher all-cause mortality, and independent association of short sleep with higher cardiovascular mortality, was observed in patients with frank CAD.