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Sleep disorders associated with risk of prostate cancer: A population-based cohort study

BMC Cancer Feb 19, 2019

Chung WS, et al. - Researchers used the Taiwan Longitudinal Health Insurance Database to assess the incidence and risk of prostate cancer in patients with sleep disorders (SDs) via Cox proportional hazards models. This study included the SD cohort, which comprised patients with newly diagnosed SDs between 2000 and 2010 (mean age: 48.0 years), and the non-SD cohort (participants were matched by age [5-year intervals], comorbidities, and medications, and were randomly sampled from the general population at a 1:1 ratio; mean age: 47.8 years). Each cohort included 41,444 patients. According to findings, prostate cancer incidence increased with age. The SD cohort vs the non-SD cohort demonstrated a higher overall incidence of prostate cancer (9.56 vs 6.36 per 10,000 person-years), with an adjusted hazard ratio of 1.42. In age-specific analysis, study participants aged ≥ 65 years in the SD cohort vs had a 1.35-fold increased risk of prostate cancer vs those in the non-SD cohort. Overall, SDs were linked to increased prostate cancer risk.

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