Skjerven HO, Rehbinder EM, Vettukattil R, et al. - In this population-based 2×2 factorial, randomised clinical trial, experts aspired to explore whether either regular skin emollients applied from 2 weeks of age, or early complementary feeding introduced between 12 and 16 weeks of age, decreased development of atopic dermatitis by age 12 months in the general infant population. This trial was conducted at Oslo University Hospital and Østfold Hospital Trust, Oslo, Norway; and Karolinska University Hospital, Stockholm, Sweden. Participants in the study were randomly assigned (1:1:1:1) utilizing computer- generated cluster randomisation based on 92 geographical living area blocks as well as eight 3-month time blocks. Two thousand six hundred ninety-seven women were enrolled between December 9, 2014, and October 31, 2016, from whom 2,397 newborn infants were registered from April 14, 2015, to April 11, 2017. Documented symptoms and signs of the skin (including itching, oedema, exanthema, dry skin, and urticaria) were no more frequent in the skin, food, and combined intervention groups than in the no intervention group. According to findings, neither early skin emollients nor early complementary feeding decreased atopic dermatitis development by 12 months of age. The use of these interventions to prevent atopic dermatitis by 12 months of age in infants was not supported in this analysis.