Skeletal disproportion in girls with Turner syndrome and longitudinal change with growth‐promoting therapy
Clinical Endocrinology Feb 12, 2021
McVey LC, Fletcher A, Murtaza M, et al. - Researchers conducted this retrospective study to characterize skeletal proportions in girls with Turner syndrome (TS) prior to any growth‐promoting therapies and to assess the change in proportions over time in relation to growth, recombinant human growth hormone (rhGH) therapy and pubertal induction with oestrogen. Data were obtained from 59 girls prior to growth hormone (rhGH) treatment and in 30 girls followed up longitudinally. Skeletal disproportion is associated with TS, which is more severe in the shortest girls and only present in half of those with milder degrees of short stature. Growth‐promoting therapy during both the childhood and pubertal phases of growth may improve disproportion. Changing the disproportionate status two years after beginning rhGH helps to predict adult height disproportion.
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