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Size at birth, infant growth, and age at pubertal development in boys and girls

Clinical Epidemiology Sep 26, 2019

Hvidt JJ, et al. - Researchers investigated if there exists a link between size at birth and infant growth and age of indicators of pubertal development in boys and girls. They hypothesized earlier pubertal age in relation to restricted fetal growth and accelerated infant growth. Participants included 15,822 boys and girls. Taking children born appropriate-for-gestational age (AGA) as a reference, the mean monthly variation in the timing of puberty was estimated between children born small-for-gestational age (SGA) and large-for-gestational age (LGA). Reaching all pubertal markers at an earlier mean age, except for breast development, was seen in girls born SGA vs girls born AGA. Compared with girls born AGA, girls born LGA reached pubertal markers later. Earlier attainment of puberty was seen in boys born SGA and LGA, compared with boys born AGA, though with CIs crossing zero. Overall, findings revealed the association of small size at birth and rapid infant growth, with early pubertal age, most consistent and pronounced in girls.
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