Noz MP, Hartman YAW, Hopman MTE, et al. - Researchers investigated the impact of reducing sedentary behavior and improving walking time on monocyte inflammatory phenotype in individuals with increased cardiovascular risk in this 16-week intervention study including 16 participants (age 64 ± 6 years, body mass index 29.9 ± 4.3 kg/m²). A device with vibration feedback to promote physical activity was used. An objective assessment of physical activity (ActivPAL), cytokine generation capacity following ex vivo stimulation in peripheral blood mononuclear cells, metabolism of peripheral blood mononuclear cells, circulating cytokine levels, and monocyte immunophenotype, was done prior to and following intervention. Findings revealed a shift of innate immune function towards a less proinflammatory state when walking time was successfully improved in people with increased cardiovascular risk. This less proinflammatory state was defined by a lower ability to generate inflammatory cytokines.