Collier CD, Su CA, Reich MS, et al. - Given that occurrence of major wound complications (MWCs) following preoperative radiation (preRT) is seen in 30% to 40% of soft tissue sarcoma (STS) patients, and that there is a lack of knowledge regarding the optimal preRT-surgery interval as well as its link with MWCs, so, researchers determined if a longer preRT-surgery interval is related to fewer MWCs vs historical controls. Patients managed by a single surgeon following preRT with limb-sparing wide resection for extremity and trunk STS were examined retrospectively. A median follow-up of 32 months was performed among 54 patients with median age of 61 years. The median preRT-surgery interval was 43 days. Surgery was received by 80% of patients 35 to 49 days post-radiation. MWCs were noted in 15% of patients and 88% happened within 40 days. In multivariate analysis, peripheral vascular disease, location in the medial compartment of the thigh, and neurovascular involvement, all were identified as predictors for MWCs. This work presents a cohort including STS patients with an extended preRT-surgery interval of ~6 weeks. In this group, a lower rate of occurrence of MWCs was reported compared with historical controls. Finally, these observations lend support to the exploration of a longer interval to decrease MWCs as well as their related morbidity.