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Single doses of diphtheria-tetanus-pertussis and poliomyelitis vaccines are sufficient to generate a booster-type response to tetanus in most migrant children

Vaccine Oct 03, 2019

Fougère Y, El Houss S, Suris JC, et al. - Since there exists a high immunization coverage for three doses of the diphtheria-tetanus-pertussis and poliomyelitis vaccines in infants, globally, and therefore, complete revaccination is not needed in most migrant children despite the absence of documentation of prior vaccinations, researchers investigated the need for additional vaccine doses using a strategy that involved administration of a single dose of a tetanus toxoid containing vaccine (TTCV) to migrant children followed by anti-tetanus toxoid serology. They estimated the basic TTCV coverage and investigated factors that could potentially determine the vaccination response. This study included 208 eligible children, with a mean age of 9 (± 4.5) years. They found long-term protection was sufficiently conferred by a single dose of TTCV in most migrant children. In settings where serotesting is accessible and economical, the abovementioned strategy can be thought of in the context of high basic vaccination coverage.
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