Ingelfinger F, Krishnarajah S, Kramer M, et al. - Researchers intended to better understand the immune dysregulation underlying myasthenia gravis (MG), and therefore, they analyzed blood and thymus samples from MG patients by using high-dimensional single-cell mass and spectral cytometry together with supervised and unsupervised machine-learning tools. They found two dysregulated subsets of inflammatory circulating memory T helper (Th) cells, by developing a comprehensive immune map. They noted that these signature Th _CD103 [CD103 ⁺ Th cells] and Th _GM cells [granulocyte–monocyte colony-stimulating factor-expressing Th cells] not only populated the diseased thymus and were decreased in the blood of MG patients but also demonstrated an inverse correlation with disease severity. Following surgical thymus removal, a rebound of both signature Th subsets was evident in the blood of MG patients, pointing towards their function as cellular markers of disease activity. Collectively, this detailed study assessing the immune landscape of MG not only offers valuable information to better understand disease pathogenesis but also proposed novel biomarkers and unveiled new potential treatment targets for management.