Cree BAC, et al. - Given that rates of worsening and progression to secondary progressive multiple sclerosis (MS) can be significantly lowered in patients treated actively vs pretreatment-era natural history studies, researchers assessed the extent to which clinical relapses and radiographic evidence of disease activity play a part in long-term accumulation of disability. A temporary increase in disability over 1-year intervals was linked to relapses, but a confirmed progression of disability was not. among people with disability progression, relative brain volume declined at a higher rate vs to those who remained stable. According to findings, long-term deterioration is often seen in patients with MS recurrence, is mostly independent of relapse activity, and is connected with quicker brain atrophy. Investigators offer the phrase “silent progression” to characterize the disability that is seen in numerous patients who meet traditional relapsing-remitting MS criteria.