Kim H, et al. - In this retrospective review of medical records from 897 patients, researchers assessed how high-risk factors (pelvic lymph node metastasis, parametrial invasion, or resection margin involvement) influence the survival of patients with cervical cancer managed with surgery followed by adjuvant chemoradiotherapy. Participants had International Federation of Gynecology and Obstetrics stage IB–IIA disease and were observed for a median duration of 57 months. The 5-year DFS rates for patients with single and multiple high-risk factors were estimated to be 80.4% and 65.7%, respectively, and the respective 5-year OS rates were 87.3% and 75.1%. The most common pattern of recurrence was distant metastasis. Findings revealed a greater likelihood of having occult distant metastasis in patients with early-stage cervical cancer having multiple high-risk factors, adenocarcinoma histologic type, and pelvic lymph node metastasis accompanied by a higher lymph node ratio post-surgery. In this patient group, consolidation with systemic chemotherapy following adjuvant therapy might be thought of in order to improve the survival outcome.