Pekmezci M, et al. – The purpose of this trial was to explore the role of trimethylation at lysine 27 of histone–H3 (H3K27me3) in the diagnosis of malignant peripheral nerve sheath tumors. It was reported that a complete H3K27me3 loss served as a moderately sensitive and relatively specific marker for its diagnosis, when the differential diagnosis comprised of synovial sarcoma and fibrosarcomatous dermatofibrosarcoma protuberans. A partial loss exhibited limited diagnostic utility. H3K27me3 status did not illustrate a prominent relationship with clinical outcome in malignant peripheral nerve sheath tumors.