Broman KK, et al. - Researchers examined the association of colorectal cancer (CRC) location with differential risk for secondary primary gastrointestinal (GI) malignancy. In this retrospective cohort of 281,413 adults with CRC (30.3% right, 35.3% left, 34.3% rectum), a second primary GI malignancy developed in 12,064 (4.3%) patients (64% CRC, 36% non-CRC). They noted higher than anticipated incidences of small intestine, bile duct, and other CRCs, and lower incidences of liver and gallbladder cancer among those with CRC at any location. After right colon cancer vs left colon or rectal cancer, higher standardized incidence ratios (SIRs) for small intestinal cancer was observed. After left colon cancer, higher esophageal cancer SIR was noted. For right colon cancer, pancreas cancer was higher than anticipated but lower for left colon and rectal cancer.