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Short-term outcomes of deceased donor renal transplants of HCV uninfected recipients from HCV seropositive nonviremic donors and viremic donors in the era of direct-acting antivirals

American Journal of Transplantation Aug 12, 2019

La Hoz RM, et al. - The short-term outcomes of adult deceased donor kidney transplants of hepatitis C virus (HCV) uninfected recipients with two distinct groups of HCV positive donors (HCV seropositive, nonviremic n = 352 and viremic n = 196) were compared with those performed using HCV uninfected donors (n = 36,934). Researchers used propensity score matching and the Organ Procurement Transplant Network data files from January 2015 to June 2019 to perform this analysis. A lower proportion of delayed graft function was observed in correlation with the transplants performed using HCV seropositive, nonviremic and viremic donors, vs the reference group. Better allograft function at 6 months posttransplant was reported for the recipients of HCV viremic donors. Furthermore, propensity score matched multivariable Cox proportional analysis revealed no statistical difference in the overall graft failure risk at 12 months posttransplant.

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