Mammoto T, Fujie K, Taguchi N, et al. - Researchers assumed that early postoperative administration of celecoxib would decrease pain scores and improve sleep quality and active range of motion after total knee arthroplasty (TKA) under general anesthesia. The patient-reported visual analog scale (VAS) pain score the second day after TKA was the primary endpoint. The sleep quality (days 1, 2, and 7 postoperatively) was considered as the secondary outcome measure. They evaluated the active knee joint range of motion on days 2 and 7 postoperatively, and VAS pain scores were assessed on postoperative days 1 to 7. They further evaluated total fentanyl consumption. After TKA, early administration of celecoxib was correlated with significantly reduced early VAS pain scores and improved sleep quality and active knee flexion angles. Therefore, after TKA, the early administration of celecoxib under general anesthesia may decrease pain and improve sleep quality and functional recovery.