Krysiak R, et al. - Researchers assessed female sexual function and depressive symptoms in three age-matched groups of young women inhabiting the Upper Silesia (a selenium-deficient and iodine-sufficient area): individuals with overt hyperthyroidism induced by Graves’ disease (group A; n=31), women with overt hyperthyroidism caused by toxic multinodular goiter or toxic adenoma (group B; n=30), and women with normal thyroid function (group C; n=34). Both groups of women with overt hyperthyroidism had lower mean total Female Sexual Function Index (FSFI) score, and all domain scores and had higher overall Beck Depression Inventory-Second Edition (BDI-II) score vs the control group, which correlated with thyrotropin and free thyroid hormone levels, as well as with the structure parameter inference approach-GT index. Compared with group B, group A had lower FSFI score as well as domain scores for desire, arousal, and sexual satisfaction, but had higher BDI-II score. In group A, the total FSFI score, desire, arousal, sexual satisfaction, and severity of depressive symptoms correlated with thyrotropin receptor antibody and thyroid peroxidase antibody titers. Based on the evidence, the investigators suggested that there may be an additive effect of excessive thyroid hormone production and thyroid autoimmunity on sexual functioning and mood.