Jankowski CM, et al. - Pooled analyses of data from 4 double-blinded, randomized controlled trials assessed the impacts of dehydroepiandrosterone (DHEA) on sex hormones, bone mineral density (BMD), fat mass and fat-free mass in 295 women and 290 men aged 55 years or older, were done. They were given DHEA or placebo tablet daily for 12 months. Conclusively, women were observed with increases in DHEAS, testosterone, (17)estradiol and insulin-like growth factor-1 (IGF-1), and men with increases in DHEAS, (17)estradiol and IGF-1 when given DHEA daily. Increased lumbar spine and trochanter BMD, and maintained total hip BMD were observed in females but a decrease in fat mass with no BMD benefit was assessed in males.