Mankiw C, Whitman ET, Torres E, et al. - The age of first alcohol consumption, transition into disordered drinking, and the prevalence of alcohol use disorder tended to differ by gender. Using a unique longitudinal dataset, researchers sought to test for potentially predispositonal gender-biases in brain organization prior to initial alcohol exposure. In order to link inking pediatric brain anatomy with adult drinking, measures of subcortical morphometry obtained in alcohol naive individuals during childhood (mean age: 9.43 years, SD = 2.06) were combined with self-report measures of alcohol use in the same individuals an average of 17 years later (N = 81, 46 males, 35 females). Per findings, males and females exhibit differential precursors of alcohol use which could yield a potential developmental basis for well identified gender-differences in precursors of peak alcohol use. Female-specific correlations were observed between subcortical anatomy and adult drinking. Localization of the effects to subregions of the amygdala and hippocampus was evident.