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Sex is associated with the persistence of non‐optimal vaginal microbiota following treatment for bacterial vaginosis: A prospective cohort study

BJOG: An International Journal of Obstetrics and Gynaecology Aug 19, 2020

Ratten LK, Plummer EL, Murray GL, et al. - Researchers aimed at ascertaining the correlations between factors and sexual practices and the composition of the vaginal microbiome (VM) of women treated for bacterial vaginosis (BV). They conducted a prospective cohort study of 75 reproductive‐age women diagnosed with clinical BV, treated with first‐line antibiotics and followed for up to 6 months. They performed assessment of vaginal swabs self‐collected by the women and questionnaires completed at enrolment, the day following antibiotics and monthly for up to 6 months until BV recurrence or no BV recurrence (n = 430 specimens). Using 16S rRNA gene amplicon sequencing, determination of bacterial composition was done. Findings revealed correlation of sex with an untreated regular sexual partner (RSP) after BV treatment with a VM comprising of non‐optimal BV‐associated bacteria. They emphasize including partner in BV treatment approaches for achieving a sustained optimal VM associated with improved health outcomes.

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