Avila JF, Vonk JMJ, Verney SP, et al. - In this investigation involving 5,258 non-Hispanic White (NHW), Black, and Hispanic men and women in the Washington/Hamilton Heights-Inwood Columbia Aging Project who were administered neuropsychological tests of memory, language, and visuospatial abilities at 18- to 24-month intervals for up to 25 years, researchers ascertained if cognitive trajectories vary between men and women across and within racial/ethnic groups. The largest baseline disparities were on visuospatial and language between NHW men and Hispanic women, and on memory between NHW women and Black men, after adjusting for age and education. Compared with Hispanic men and NHW women, memory and visuospatial decline were steeper for Black women, respectively. This research provides an important first step in understanding variations on cognitive trajectories between race/ethnicity and sex/gender by showing variation through race/ethnicity in sex/gender differences.