Lin CY, et al. - Researchers performed this retrospective analysis to determine sex differences in platelet count and neutrophil-to-lymphocyte ratio (NLR) in predicting overall survival for select cancer types, focusing on head and neck squamous cell carcinoma (HNSCC). This study included 9,365 patients seen in a tertiary teaching hospital with nine different primary tumors. Peripheral blood samples from these subjects were analyzed, as well as HNSCC RNA-sequencing data from The Cancer Genome Atlas. Platelet count better predicted overall survival in males, while NLR was more predictive for females. Lymphocyte count was also more associated with survival than neutrophil count in females. In females vs males, high tumor infiltration by T lymphocytes was more clearly linked with survival. For the first time, sex bias in the clinical utility of platelet, granulocyte and lymphocyte counts as biomarkers to prognosticate HNSCC patients was comprehensively demonstrated in this study.