Nanna MG, Wang TY, Xiang Q, et al. - Since less aggressive lipid management has been received by female patients, historically, compared with male patients, researchers focused on sex differences in the use of statin therapy, guideline-recommended statin dosing, and causes for undertreatment by analyzing a nationwide registry of outpatients with or at risk for atherosclerotic cardiovascular disease, named as the Patient and Provider Assessment of Lipid Management Registry. After adjusting for demographics, socioeconomic factors, clinical features, patient beliefs, and provider features, both overall and guideline-recommended intensity statin use continued to vary by sex. The likelihood of being treated with any statin or guideline-recommended statin intensity was less among women eligible for statin therapy vs men. The observed sex differences in statin use were attributable to a less frequent prescription of statin in women along with a more frequent decline and discontinuation of treatment among women.