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Sex differences in risk factors for aneurysmal subarachnoid haemorrhage: Systematic review and meta-analysis

Journal of the Neurological Sciences Sep 06, 2019

Rehman S, Sahle BW, Chandra RV, et al. - Since aneurysmal subarachnoid haemorrhage (aSAH) affects women disproportionally, researchers explored sex differences in aSAH risk factors through a systematic review and meta-analysis. Case-control/cohort studies with sex-specific risk factors for aSAH were searched until November 2017. When a risk factor was reported in ≥ 2 studies, meta-analysis was conducted. Of 31 studies, 22 have meta-analysis eligibility. Female sex was linked to greater odds of aSAH. It was noted that alcohol, high alanine aminotransferase levels, and some gene variants raised the risk of aSAH in men, whereas reproductive factors, divorce and certain genetic variations raised the risk in women. High levels of aspartate aminotransferase in men and, diabetes and parity in women lessened aSAH risk. Sex-specific re-analysis of existing studies of aSAH risk factors were recommended. Known risk factors such as hypertension, smoking and alcohol consumption for aSAH in men and women should be targeted.
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