Davio A, Woolcock H, Nanba AT, et al. - Researchers conducted the study for comparing the circulating 11-oxyandrogen concentrations in men and women across adult ages. Mass spectrometry was used to measure testosterone (T), androstenedione (A4), 11β-hydroxytestosterone (11OHT), 11-ketotestosterone (11KT), 11β-hydroxyandrostenedione (11OHA4), 11-ketoandrostenedione, and morning cortisone sera obtained from adults in outpatient setting. They conducted double immunofluorescence of 3β-hydroxysteroid dehydrogenase type 2 and cytochrome b5 in adrenal tissue from 19 men, age 23-78 years. Study participants included 590 patients (319 men), 18-97 years of age, 84% white. The production of 11OHA4 and 11OHT is sustained with aging in both genders in contrast with traditional androgens. Bioactive androgen 11KT decreases in aging males, but not females.