Sex and age as determinants for high blood pressure in pediatric renal transplant recipients: A longitudinal analysis of the CERTAIN Registry
Pediatric Nephrology Jan 24, 2020
Sugianto RI, Schmidt BMW, Memaran N, et al. - In this retrospective study, researchers analyzed pediatric renal transplant recipients (n = 336; 62% males) from the Cooperative European Pediatric Renal Transplant Initiative Registry (CERTAIN), to determine how blood pressure (BP) distribution and control vary between age groups and if gender and age interact and potentially influence BP post-transplantation, given pediatric renal transplant patients are known to have a high prevalence of arterial hypertension. Complete BP measurement at discharge and 1, 2 and 3 years after transplant was available. This large European cohort exhibited poor BP control during the first 3 years. A significant link with higher systolic BP z-score was shown by factors such as younger age, shorter time since transplantation, male gender, higher BMI, high cyclosporine A (CSA) trough levels, and a primary renal disease other than congenital anomalies of the kidney and urinary tract. Among older girls that possibly had started puberty already, a significant link between high CSA and higher systolic BP was identified in the sex-stratified analysis. With the help of age- and gender-specific risk profiles, certain recipient groups were recognized for whom more frequent BP monitoring (ie, young children) or different choices of immunosuppression (ie, older girls) may be beneficial.
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