Murase T, et al. – This study was performed in Japanese patients with severe hypertriglyceridemia to characterize the causes of and responses to therapy in these cases. Etiology of severe hypertriglyceridemia was uncertain in many patients. There was no known genetic diversity between populations having primary genetic forms of severe hypertriglyceridemia. Compared to western countries, fewer cases of estrogen–induced hypertriglyceridemia were documented, in the acquired forms. On the basis of clinical experience, the cause of most hypertriglyceridemia remained uncertain.