Serum vitamin D level is associated with smell dysfunction independently of aeroallergen sensitization, nasal obstruction, and the presence of allergic rhinitis in children
Pediatric Allergy and Immunology Aug 30, 2020
Shin YH, Ha EK, Kim JH, et al. - Researchers intended to determine if there is a connection between 25‐hydroxyvitamin D levels and the severity of smell dysfunction in children. The olfactory threshold score was measured in a total of 518 children (10 to 12 years old, 264 boys) utilizing the Sniffin’ Stick kit, and the children were divided into tertiles based on an olfactory threshold score. Serum 25‐hydroxyvitamin D (25[OH]D) level, common aero‐allergen specific IgEs, rhinitis severity were also evaluated with visual analogue scale, and the Total Four Symptom Score (T4SS), and pre‐ and post‐decongestant nasal patency with acoustic rhinometry. Compared with children with 25(OH) D levels of ≥ 20.0 ng/mL, those with 25(OH) D deficiency had significantly decreased mean olfactory threshold scores. 25‐hydroxyvitamin D is associated significantly with smell dysfunction regardless of aeroallergen sensitization, nasal obstruction, and the presence of allergic rhinitis. This finding might provide insight into the mechanisms involved in olfactory dysfunction development.
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