Ferreira A, Silva N, Furtado MJ, et al. - Researchers intended to determine if there is an association between serum 25-hydroxyvitamin D 25(OH)D levels and age-related macular degeneration (AMD) through a systematic review and meta-analysis. A four-database search (PubMed, ISI Web of Science, Cochrane, and Scopus) was conducted from beginning to May 2020 using the MeSH terms: (“Macular Degeneration” OR “Age-related macular degeneration” OR “Retinal degeneration” OR “Macula lutea”) AND (“Vitamin D” OR “Ergocalciferols” OR “Cholecalciferol” OR “25-Hydroxyvitamin D”). Eighteen observational studies recruiting 75,294 patients after a selection process among 375 original abstracts were chosen. According to the results, there is no clear evidence of a definitive connection between serum 25(OH)D and AMD risk, mainly due to heterogeneity of the study procedures and absence of longitudinal designs.