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Serum soluble triggering receptor expressed on myeloid cells 2 as a biomarker for incident dementia: The Hisayama Study

Annals of Neurology Jan 25, 2019

Ohara T, et al. - Among 1,349 Japanese community residents (aged 60 and older) with no dementia who were followed prospectively for 10 years (2002–2012), researchers examined the relationship between serum soluble triggering receptor expressed on myeloid cells 2 (sTREM2), a soluble type of an innate immune receptor expressed on the microglia, and the dementia risk. In the general elderly Japanese population, a significant link was found between increased serum sTREM2 levels and the risk of developing all-cause dementia, Alzheimer's disease, and vascular dementia. Significantly higher multivariable-adjusted risks of developing all-cause dementia, AD, and VaD were seen in those with the highest quartile of serum sTREM2 levels vs those with the lowest.

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