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Serum procalcitonin levels predict acute kidney injury in critically ill patients

Nephrology Oct 05, 2017

Jeeha R, et al. - This study investigated any possible association of admission procalcitonin (PCT) with subsequent development of AKI in a general population of critically ill patients. In the non-septic patient population, subsequent AKI development was significantly associated with an elevated admission PCT.

Methods

  • Researchers undertook this retrospective observational study at a multidisciplinary intensive care unit (ICU) over a period of 1 year.
  • Using the KDIGO criteria, they assessed AKI development within the first week of ICU admission in adult patients who had a PCT performed on admission and who did not have CKD or AKI on admission.
  • They assessed the link between PCT on admission and the development of AKI for the entire cohort and for septic and non-septic subgroups.

Results

  • This study included 201 patients.
  • Data showed that the incidence of AKI in the first 7 days of ICU admission was 36.8%.
  • Univariate analysis indicated a significant association of PCT, age, the presence of shock on admission, and sepsis with AKI.
  • Furthermore, age, shock and sepsis remained independent predictors of AKI, while PCT was no longer significant, as demonstrated in multivariable analysis of the entire cohort.
  • In addition, separate analysis of septic and non-septic patients showed that a PCT ≥10ng/ml remained the only significant predictor of AKI in the non-septic patients (OR 4.430; 95% CI 1.464-13.399), but was not an independent predictor of AKI in septic patients.

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