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Serum potassium in chronic kidney disease: Prevalence, patient characteristics and clinical outcomes

Internal Medicine Journal Dec 16, 2020

Brookes EM, Snider J, Hart GK, et al. - In order to find out the role of dyskalaemia in hospital in‐patients, researchers evaluated the epidemiology of potassium disorders among chronic kidney disease (CKD) patients and the relationship between admission potassium and inpatient mortality or intensive care unit (ICU) requirement. A retrospective hospital‐based cohort study was conducted to include a total of 11,156 patients with eGFR< 60 mL/min/1.73m2 admitted to Austin Health between 2014 and 2018 and who had an admission potassium value. Factors associated with hyperkalaemia (≥ 5.5 mmol/L) and hypokalaemia (< 3.5 mmol/L) were identified by performing Multivariate logistic analysis. They obtained odds ratios for inpatient mortality and ICU admission between potassium categories by multivariate regression with adjustments for demographics, renal function, and comorbidities. The data exhibited that derangements in potassium frequently occur in CKD inpatients and are independently correlated with higher mortality and ICU requirement. Future trials are needed to ascertain if interventions to maintain normokalaemia improve outcomes in this population.

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