Gruppen EG, et al. – In this population-based study involving 8,224 participants of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort, researchers cross-sectionally examined the relationship between serum paraoxonase-1 (PON-1) activity and alcohol consumption when taking account of high-density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apoA-I), its major apolipoprotein. The investigators observed an increase in serum PON-1 activity in association with alcohol consumption, but its effect seemed to reach a plateau with alcohol consumption of 10–30 g/d.