Aghamelu O, Buggy P, Smith G, et al. - An association between certain anesthetic techniques and tumor metastasis following breast cancer surgery has been suggested in some experimental and retrospective clinical studies. Among breast cancer patients, an elevated risk of metastasis has been noted to be linked with expression of neutrophil extracellular trapping (NETosis), an immunological process, whereby neutrophils engulf tumor antigen then degranulate, leaving a serologic marker. Researchers here conducted a parallel‐group, randomized controlled trial examining the effect of two distinct anesthetic techniques on the expression of NETosis in women who underwent potentially curative breast cancer surgery. They randomly assigned a subset of women (n = 40) undergoing breast cancer resection surgery, who were partaking in a larger trial (NCT00418457), to receive volatile general anesthesia (GA) or propofol GA combined with paravertebral regional anesthesia (PPA) for their surgery. Assessment of serum obtained and stored before and 24 hours postoperatively revealed no effect of anesthetic technique on NETosis expression in breast cancer patients, suggesting it to be a non-viable marker of the effect of anesthetic technique on breast cancer recurrence.