Kook HY, et al. - Investigators estimated 887 individuals to analyze the ankylosing spondylitis (AS)-specific microRNA (miR) in sera of subjects with AS. They isolated total RNAs from sera of candidates with AS, patients with rheumatoid arthritis (RA), and healthy controls (HC) using miRNeasy Serum/Plasma Kit. They noticed a lower expression of serum miR-214 in AS after validation by qPCR. They observed the level of miR-214 of AS significantly associated with Ankylosing Spondylitis Disease Activity Score—C-reactive protein. Yet, other disease-specific variables exhibited no statistical significance: gender, peripheral arthritis, enthesitis, dactylitis, psoriasis, inflammatory bowel disease, human leukocyte antigen-B27 positivity, use of non-steroidal anti-inflammatory drugs, and use of tumor necrosis factor-blocker in the last 3 months.